What Kyzatrex is
Kyzatrex is testosterone undecanoate in a soft capsule, an FDA-approved way to replace testosterone by mouth. You take it twice a day, once with breakfast and once with dinner. There are no injections, no gels to transfer to a partner and no in-office procedures.
The capsule works differently from older oral testosterone. Testosterone undecanoate is absorbed along with fat from your meal into the lymphatic system, which lets much of it bypass the first pass through the liver. That is why MedlinePlus instructs you to take it with food twice daily at about the same times each day.
The Kyzatrex label approves it for men with confirmed low testosterone from testicular or pituitary causes. It also notes that safety and effectiveness in age-related low testosterone have not been established, a limitation shared by every testosterone product.
Who it suits, and who should not take it
Kyzatrex tends to suit men who:
- Want to avoid needles entirely (our page for men who dislike needles covers the alternatives)
- Travel often and prefer a capsule to injection supplies
- Eat two regular meals a day and can stick to a twice-daily routine
- Want the option to adjust the dose in small steps
It is a poor fit if you have uncontrolled high blood pressure, which the label says it is not recommended for. It is contraindicated in breast cancer and known or suspected prostate cancer. Men trying to conceive should not use any form of testosterone, because it suppresses sperm production. If you often skip meals or work irregular shifts, twice-daily dosing with food can be harder to keep up than a weekly shot.
Why the label carries a blood pressure warning
All testosterone products now warn about blood pressure. In February 2025 the FDA required class-wide changes: it added TRAVERSE trial results, removed the boxed warning language on cardiovascular outcomes, and required blood pressure information on every product.
Oral testosterone undecanoate was studied with 24-hour ambulatory blood pressure monitoring, the most sensitive way to catch small rises. In the Kyzatrex study, average systolic pressure rose 1.7 mm Hg at 4 months and 1.8 mm Hg at 6 months. In men already on blood pressure medicines, the rise was 3.4 mm Hg at 4 months. The label explains that sustained increases can raise cardiovascular risk over time.
The label once carried this as a boxed warning; that box was removed in July 2025, and the warning now sits in the main warnings section. The advice did not change: check blood pressure periodically, especially if you already have hypertension. Our article on whether TRT can raise blood pressure puts the numbers in context, and men already treated for hypertension can read our page for men on blood pressure medicines.
How the clinic decides
Kyzatrex is one of four testosterone options at Ultimate Male, alongside injections, Pellecome pellets and HCG. The choice comes after labs and a one-on-one consultation.
The starting point is the TRT pre-screening panel: total testosterone, estradiol, PSA and a complete blood count. The label, like the AUA guideline, requires low morning testosterone on at least two separate days before starting. Your provider also looks at your blood pressure history and medicines, since some medicines can push blood pressure higher when combined with testosterone. If you are deciding between a capsule and a shot, our comparison of Kyzatrex and testosterone injections lays out the trade-offs.
Your first months: the check schedule
| When | What is checked | Why |
|---|---|---|
| Before starting | Two morning testosterone tests, hematocrit, PSA, blood pressure | Confirms the diagnosis and sets baselines |
| Day 7 | Testosterone, drawn 3 to 5 hours after your morning dose | The label’s first dose-adjustment point |
| 7 days after any dose change | Testosterone, same timing | Confirms the new dose |
| About every 3 months | Hematocrit | Testosterone can thicken the blood |
| Periodically | Blood pressure and lipids | Label warnings for both |
The label starts most men at 200 mg twice daily and allows adjustment from 100 mg once a day up to 400 mg twice a day, based on that 3 to 5 hour level. Your provider sets every change; do not adjust on your own. A home blood pressure cuff makes the periodic checks easy, and many men bring a week of readings to their follow-ups.
Side effects and safety
In the label’s 6-month study, high blood pressure was the most common side effect. Other effects named in the label include breast enlargement (gynecomastia), a rise in hematocrit and changes in cholesterol. The label also lists blood clots in the legs or lungs among its warnings.
Some symptoms need emergency care rather than a call to the clinic: chest pain, sudden shortness of breath, one-sided weakness or face drooping, or painful swelling in one leg. Call 911 or go to the ER.
Paying for Kyzatrex
Ultimate Male is a cash-pay clinic, does not publish prices and does not bill insurance. Visits are paid individually with no membership, and longer plans can be bundled; the medication itself is a separate cost, covered on our page on Kyzatrex cost. Itemized receipts support FSA, HSA and out-of-network claims. Financing is available through CareCredit, Prosper Healthcare Lending and Afterpay, and Arcadia Police Officers Association members receive 13% off TRT.
Is a capsule right for you?
The answer comes from your labs, your blood pressure and your daily routine. Call 626-319-5261 for the free 10-minute call or book a TRT consultation at our San Gabriel or Downey clinic. If Kyzatrex fits, you leave with a dose, a meal routine and dates for each check; if it does not, you hear which testosterone therapy option fits better and why.
