Answer · ED Medications

Why does Cialis give me back pain?

Short answer

Back and leg muscle aches are a recognized side effect of tadalafil (Cialis), reported more often than with placebo. The label says they usually start 12 to 24 hours after a dose and fade within 48 hours. The cause is unknown, and trial testing found no muscle or kidney damage. The usual fixes are a lower dose, daily low dosing, new timing or a different medicine.

By the Ultimate Male team · Updated October 8, 2026

Clinician examining a man's knee

How common is back pain on Cialis?

Common enough to be listed among its main side effects. The Cialis label names back pain, muscle aches and pain in the limbs among the reactions seen in at least 2% of men, and the rate climbs with the as-needed dose.

How it was taken Back pain on tadalafil Back pain on placebo
As needed, 5 mg 3% 3%
As needed, 10 mg 5% 3%
As needed, 20 mg 6% 3%
Once daily, 2.5 mg or 5 mg (12-week ED trials) 3% 1%
Once daily, 5 mg (BPH trials) 2.4% 1.4%

The pattern is useful: the higher as-needed doses carry the most back pain, and the low daily doses carry less. Our comparison of sildenafil and tadalafil shows how the side effect profiles differ more broadly.

What does it feel like, and when does it start?

A diffuse muscular ache rather than a sharp, joint-type pain. The label describes it as discomfort on both sides of the lower back, buttocks, thighs or mid-back, often worse when lying down. In the trials, it generally began 12 to 24 hours after a dose and typically cleared within 48 hours. Most cases were mild or moderate and settled without treatment.

That timing matters. An evening dose can bring the ache on overnight, just when lying down makes it more noticeable, so it often shows up as next-morning stiffness.

Is it a sign of damage?

No sign of damage turned up when it was looked for. The label reports that testing for inflammation, muscle injury or kidney damage found no medically significant underlying problem. The cause is still not known.

That said, the label pattern is specific: a muscular ache that starts 12 to 24 hours after a dose and fades within two days. Pain that is severe, lasts longer than that, or feels different from a muscle ache is not that pattern and should be checked by a clinician. MedlinePlus lists back, muscle, arm and leg pain among the side effects to report if they are severe or do not go away.

What changes usually help?

Several, and your provider can try them in order:

  1. A lower dose. The table above shows back pain rises with the as-needed dose, so a smaller dose may keep the benefit with less ache.
  2. Daily low-dose tadalafil. In separate trials, the daily doses were linked with lower rates than 20 mg as needed. Our page on daily versus as-needed tadalafil compares the two.
  3. A change in timing. Because the ache tends to arrive 12 to 24 hours later, shifting when you take a dose can move it away from sleep or a hard training day.
  4. A pain reliever when needed. The label notes that acetaminophen or an anti-inflammatory such as ibuprofen was generally effective when treatment was needed. Check with your provider first if you have kidney disease, stomach ulcers or take a blood thinner.
  5. A different medicine. Back pain is less distinctive with sildenafil, according to the Viagra label, so switching may solve it for some men.

Do not split tablets or change your dose without your provider’s go-ahead.

Could it be something other than Cialis?

Sometimes, yes. Men who lift, run or sit for long hours have plenty of other reasons for a sore back, and a new medicine is an easy thing to blame. If the ache does not follow the 12-to-24-hour pattern after a dose, or it shows up on days you did not take tadalafil, look for another cause. Our page for lifters over 40 covers common training-related aches.

How Ultimate Male adjusts tadalafil when side effects get in the way

At our San Gabriel and Downey clinics, your provider asks when the ache starts, how long it lasts and how it affects your sleep and training before changing anything. The fix is usually a dose, schedule or medicine change rather than stopping ED treatment altogether.

Our answer on how long Cialis lasts explains why its side effects can linger. If back pain is putting you off treatment, call 626-319-5261 for a free 10-minute call, or read about the ED medications we offer.

questions

Related questions.

Why does Cialis give me back pain?

Still unsure? Take the free assessment

Does Viagra cause back pain too?
It can, but less distinctly. In the sildenafil label's fixed-dose trials, back pain was reported by 3 to 4% of men on the drug and 2% on placebo, and in its flexible-dose trials the rates were the same as placebo.
Will the back pain go away if I keep taking Cialis?
In the trials it was usually mild or moderate. In the label's one-year open-label extension study, 5.5% of men reported back pain at some point. If it keeps disrupting your sleep or training, tell your provider rather than putting up with it.
Is it safe to exercise with the ache?
The label describes a mild to moderate muscular ache, so normal activity is generally reasonable. Do not push heavy lifts through sharp pain, and mention it at your next visit.

Sources

  1. CIALIS (tadalafil) tablet, film coated: label · DailyMed, National Library of Medicine
  2. VIAGRA (sildenafil citrate) tablet, film coated: label · DailyMed, National Library of Medicine
  3. Tadalafil: MedlinePlus Drug Information · MedlinePlus, National Library of Medicine

This page is general education, not medical advice. A licensed clinician must review your symptoms, history and labs before any treatment decision. For chest pain, trouble breathing, signs of stroke or an erection lasting over four hours, call 911.

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