Article · Testosterone Therapy

What Causes Low Testosterone in Men Under 40?

Short answer

Low testosterone before 40 usually has an identifiable cause. Common contributors include obesity, sleep disorders, opioid pain medicines, some corticosteroids, past anabolic steroid use, serious illness, testicular injury or infection, genetic conditions and problems with hormone signals from the pituitary or hypothalamus. Diagnosis needs symptoms plus repeat low morning tests, and fertility plans should be raised before any treatment.

By the Ultimate Male team · Updated October 8, 2026 · First published September 23, 2026

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Can younger men have low testosterone?

Yes. Low testosterone can occur before age 40. Feeling unlike yourself in your twenties or thirties can raise questions about testosterone, and for men in San Gabriel and Downey, an evaluation starts with understanding the cause of persistent symptoms and whether hormone testing is appropriate.

Possible contributors include obesity, certain medicines, sleep disorders, testicular problems and conditions affecting hormone signals from the brain. Symptoms alone cannot establish the diagnosis. The Endocrine Society recommends confirming low levels with repeat morning testing alongside a symptom assessment.

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What can cause low testosterone before 40?

The causes fall into two broad groups: things that suppress an otherwise healthy system, and problems in the testes or the brain’s hormone signals.

Sleep, illness and recovery can affect the picture

Sleep disorders, severe illness, poor nutrition and excessive exercise can be associated with lower testosterone, according to the Endocrine Society. Tell your clinician if testing followed an illness or a period of unusual physical strain. A result needs context before it becomes a treatment decision. Our page on sleep apnea and low testosterone covers how disrupted sleep and hormone levels connect.

Weight and metabolic health deserve attention

Obesity can affect testosterone and reduce SHBG, a protein that carries the hormone in the blood. This can complicate interpretation of a total testosterone result. Your clinician may consider free testosterone when appropriate rather than treating every low total number as the same problem; MedlinePlus lists obesity among the causes of male hypogonadism and notes that lower SHBG can make diagnosis harder, and our page on obesity and low testosterone explains the two-way link.

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Medicines and anabolic steroids can contribute

Opioid pain medicines and some corticosteroids can affect testosterone production; our page on opioid-induced low testosterone explains what can change when the medicine does. Anabolic steroid use is another possible contributor. Bring a complete list of medicines, supplements and hormone products to your appointment, including products obtained outside a pharmacy. Do not stop a medicine you have been given without talking to the clinician who manages it.

Sometimes the cause involves the testicles or hormone signals

Testicular injury, certain infections, cancer treatments and genetic conditions can impair testosterone production. Other causes involve the pituitary or hypothalamus, which help regulate hormone signals. Identifying the source matters because different causes can require different management, a point both MedlinePlus and the Endocrine Society guideline make.

Man writing notes at a kitchen table before a health visit

What should an evaluation include?

An evaluation should pair a careful history and exam with the right blood tests, repeated when needed. A clinician reviews your symptoms, history, medicines and examination findings. When testosterone deficiency is suspected, repeat morning fasting testosterone testing helps confirm it, as the Endocrine Society guideline recommends.

Test What it helps show
Repeat morning total testosterone Whether low levels are consistent, not a one-off
Free testosterone and SHBG Usable testosterone when weight or SHBG skews the total
LH and FSH Whether the problem starts in the testes or in the brain’s signals
Other tests, as findings suggest Prolactin, iron studies or imaging, depending on the picture

For more detail about the testing conversation, read our guide to lab work before starting TRT. Bring prior results and a short timeline of what changed so the visit can focus on your questions.

Does confirmed low testosterone always mean TRT?

No; treatment depends on the cause. Some contributing conditions can improve without testosterone replacement, while other forms of hypogonadism need ongoing treatment. If TRT is considered, discuss expected benefits, alternatives and monitoring.

Testosterone can raise blood pressure, a risk the FDA’s 2025 class-wide labeling changes added to every testosterone product, so readings are checked before and during treatment.

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Discuss fertility before starting testosterone

Testosterone treatment can suppress sperm production. If biological children are part of your plans, raise that before treatment starts. A reproductive specialist can discuss evaluation, alternatives and whether sperm preservation is appropriate.

Recovery after stopping testosterone can take time, and treatment should not begin with an assumption that fertility will be unaffected, as the American Society for Reproductive Medicine explains. Our article on whether TRT affects fertility covers the options in more depth.

Take the next step in San Gabriel

Prepare three questions for your visit: What could explain my symptoms? What testing will clarify the cause? How would my health and family plans affect treatment choices?

Explore testosterone therapy at Ultimate Male or request a consultation to discuss an evaluation in San Gabriel. Ultimate Male also serves patients at its Downey clinic, with same-day, on-site blood draws at both locations.

questions

Common questions.

What Causes Low Testosterone in Men Under 40?

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Is one low testosterone result enough?
No. A diagnosis generally requires relevant symptoms or signs together with consistently low testosterone, confirmed with repeat testing. Ask how timing and your health at the time of the blood draw affect interpretation.
Can treating the underlying cause help?
Sometimes. Reversible contributors may improve with appropriate care, while permanent testicular or hormonal disorders may need longer-term management. The cause helps determine the plan.
Can I start TRT if I want children soon?
Tell your clinician before starting. The Endocrine Society recommends against testosterone therapy when fertility is planned in the near term, and a reproductive specialist can help assess your options.

Sources

  1. Hypogonadism (low testosterone) · Endocrine Society
  2. Testosterone Therapy in Men with Hypogonadism guideline · Endocrine Society
  3. Male hypogonadism · MedlinePlus Medical Encyclopedia
  4. FDA issues class-wide labeling changes for testosterone products · U.S. Food and Drug Administration (2025)
  5. Testosterone use and male infertility · American Society for Reproductive Medicine

This page is general education, not medical advice. A licensed clinician must review your symptoms, history and labs before any treatment decision. For chest pain, trouble breathing, signs of stroke or an erection lasting over four hours, call 911.

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